Billy Carol Anderson Sr., 62, was found guilty of seven counts of touching a child for lustful purposes after a week-long trial.
"The number of lives and childhoods that this defendant has destroyed is unlike any case I have ever seen," said Assistant District Attorney Angel Myers, who tried the case along with ADA Justin Lovorn.
"I can only hope today's verdict and sentence will be a catalyst to start the healing for the victim in this case and the victims of past," she said.
Circuit Judge Robert Krebs sentenced Anderson to 105 years to serve day-for-day in custody of the Mississippi Department of Corrections.
The man was indicted on July 23, 2013, for sexually abusing a female child between the ages of 12 and 15 for more than two years.
The George County Sheriff's Office investigated the case, which led to the discovery of Anderson's long history of abusing children.
"The defendant's ability to manipulate, control and abuse children ended today," Lovorn said. "I am proud of the verdict and the strong sentence handed down by the court."
Lawrence said Anderson's ability to harm children in George County is over.
"Sometimes I wish the wheels of justice can turn faster, but in this case they turned true and correct," Lawrence said. "This man will never have the ability to touch or harm another child for his sexual purposes."